Issue 20, 2017
From the journal:

Organic & Biomolecular Chemistry

Synthesis of cyclooxygenase metabolites of 8,9-epoxyeicosatrienoic acid (EET): 11- and 15-hydroxy 8,9-EETs†

Bogdan Barnych,a   Amy A. Rand,a   Tomas Cajka,b   Kin Sing Stephen Leea  and  Bruce D. Hammock*a  

* Corresponding authors

a Departments of Entomology and Nematology and UC Davis Comprehensive Cancer Center, University of California Davis, One Shields Avenue, Davis, California 95616, USA
E-mail: bdhammock@ucdavis.edu

b UC Davis Genome Center-Metabolomics, University of California Davis, One Shields Avenue, Davis, California 95616, USA

Abstract

COX metabolites of 8,9-EET, previously observed as potent mitogenic lipid mediators, were synthesized for the first time by using two synthetic approaches. These synthetic materials allow for structural confirmation of COX metabolites of 8,9-EET and further study of their biological roles.

Graphical abstract: Synthesis of cyclooxygenase metabolites of 8,9-epoxyeicosatrienoic acid (EET): 11- and 15-hydroxy 8,9-EETs

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Article information

DOI
https://doi.org/10.1039/C7OB00789B
Article type
Paper
Submitted
29 Mar 2017
Accepted
19 Apr 2017
First published
25 Apr 2017

Org. Biomol. Chem., 2017,15, 4308-4313

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Synthesis of cyclooxygenase metabolites of 8,9-epoxyeicosatrienoic acid (EET): 11- and 15-hydroxy 8,9-EETs

B. Barnych, A. A. Rand, T. Cajka, K. S. S. Lee and B. D. Hammock, Org. Biomol. Chem., 2017, 15, 4308 DOI: 10.1039/C7OB00789B

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