Issue 30, 2017

Selective construction of polycyclic spirooxindoles via a Cu(OTf)2/HOTf-catalyzed domino reaction of o-arylalkynylacetophenones and 3-phenacylideneoxindoles

Abstract

Under the combined catalysis of Cu(OTf)2/HOTf, the domino annulation reaction of o-arylalkynyl acetophenones with 3-phenacylideneoxindoles in refluxing acetonitrile selectively afforded functionalized spiro[indoline-3,7′-tetrapheno[7,6-bc]furans] and spiro[indeno[1,2-b]naphtho[2,1-d]furan-7,3′-indolines] depending on the electronic effect of the substituents on both substrates.

Graphical abstract: Selective construction of polycyclic spirooxindoles via a Cu(OTf)2/HOTf-catalyzed domino reaction of o-arylalkynylacetophenones and 3-phenacylideneoxindoles

Supplementary files

Article information

Article type
Paper
Submitted
26 May 2017
Accepted
01 Jul 2017
First published
03 Jul 2017

Org. Biomol. Chem., 2017,15, 6353-6357

Selective construction of polycyclic spirooxindoles via a Cu(OTf)2/HOTf-catalyzed domino reaction of o-arylalkynylacetophenones and 3-phenacylideneoxindoles

R. Yang, J. Sun, Q. Sun and C. Yan, Org. Biomol. Chem., 2017, 15, 6353 DOI: 10.1039/C7OB01292F

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