Issue 30, 2017

Copper-catalyzed synthesis of arylcarboxamides from aldehydes and isocyanides: the isocyano group as an N1 synthon

Abstract

An interesting radical coupling reaction of aromatic aldehydes with isocyanides was disclosed for the synthesis of amides catalyzed by copper. According to the experimental results and mechanistic study, the isocyano group acted as an N1 synthon rather than exhibiting the carbene-like reactivity, exploiting a new reactivity profile of isocyanides.

Graphical abstract: Copper-catalyzed synthesis of arylcarboxamides from aldehydes and isocyanides: the isocyano group as an N1 synthon

Supplementary files

Article information

Article type
Communication
Submitted
15 Jun 2017
Accepted
10 Jul 2017
First published
10 Jul 2017

Org. Biomol. Chem., 2017,15, 6314-6317

Copper-catalyzed synthesis of arylcarboxamides from aldehydes and isocyanides: the isocyano group as an N1 synthon

J. Liu, X. Shen, Z. Liu and X. Wang, Org. Biomol. Chem., 2017, 15, 6314 DOI: 10.1039/C7OB01449J

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