Issue 34, 2017

2,4-Diamino-1,3,5-triazine-enabled Cu-catalyzed direct sulfonamidation of aromatic C–H bonds

Abstract

An efficient copper acetate catalyzed sulfonamidation of arenes via C–H bond activation directed by a 2,4-diamino-1,3,5-triazine chelating group under oxygen as a terminal oxidant has been developed. The reaction shows good regioselectivity and functional group tolerance, as well as providing a straightforward methodology for the preparation of ortho-monosulfonamidated arene derivatives in moderate to high yields. The sulfonamidation at the gram scale can be performed with a good yield.

Graphical abstract: 2,4-Diamino-1,3,5-triazine-enabled Cu-catalyzed direct sulfonamidation of aromatic C–H bonds

Supplementary files

Article information

Article type
Paper
Submitted
28 Jul 2017
Accepted
03 Aug 2017
First published
15 Aug 2017

Org. Biomol. Chem., 2017,15, 7212-7217

2,4-Diamino-1,3,5-triazine-enabled Cu-catalyzed direct sulfonamidation of aromatic C–H bonds

C. Song, T. Wang, T. Yu, D. Cui and C. Zhang, Org. Biomol. Chem., 2017, 15, 7212 DOI: 10.1039/C7OB01872J

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