Issue 39, 2017

Iridium-catalyzed direct C–H amidation of anilines with sulfonyl azides: easy access to 1,2-diaminobenzenes

Abstract

An Ir(III)-catalyzed regioselective C–H amidation of anilines with sulfonyl azides is described. The developed protocol has good compatibility with diverse functional groups, efficiently providing the monoamidated products with good to excellent yields under mild reaction conditions. Furthermore, the 2-pyrimidyl and sulfonyl moieties in the amidated products can readily be removed, offering the synthetically useful 1,2-diaminobenzene scaffold.

Graphical abstract: Iridium-catalyzed direct C–H amidation of anilines with sulfonyl azides: easy access to 1,2-diaminobenzenes

Supplementary files

Article information

Article type
Paper
Submitted
31 Jul 2017
Accepted
13 Sep 2017
First published
13 Sep 2017

Org. Biomol. Chem., 2017,15, 8302-8307

Iridium-catalyzed direct C–H amidation of anilines with sulfonyl azides: easy access to 1,2-diaminobenzenes

L. Wang, Z. Yang, M. Yang, R. Zhang, C. Kuai and X. Cui, Org. Biomol. Chem., 2017, 15, 8302 DOI: 10.1039/C7OB01899A

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