Transition metal-catalyzed C–H bond functionalization in multicomponent reactions: a tool toward molecular diversity

Abstract

Transition metal-catalyzed C–H bond functionalization has numerous applications in organic synthesis as a powerful type of bond transformation. In particular, the combination of C–H functionalization with other types of chemical transformations in the manner of multicomponent reactions is an even more beneficial tool in the synthesis of small organic molecules because such reactions provide a platform for the rapid generation of high molecular diversity and complexity by making use of the advantages of both latent C–H bond transformation and the multicomponent reaction. Herein, we provide a review highlighting the research advances in the multicomponent reactions built upon transition metal-catalyzed C–H bond functionalization. The content spans from the reactions featuring the functionalization of C(sp³)–H, C(sp²)–H and C(sp)–H bonds over the last decade.