Issue 47, 2017

Palladium-catalyzed tandem reaction of 2-chloroquinoline-3-carbaldehydes and isocyanides

Abstract

A facile domino reaction of 2-chloroquinoline-3-carbaldehydes in one and two equivalents of isocyanide has been investigated. Three-component reactions of 2-chloroquinoline-3-carbaldehydes, isocyanides and amines are also described. In this Pd-catalyzed reaction under controlled conditions, three novel types of quinoline derivatives were formed via amidation, lactamization or carbamate formation along with the formation of C–C, C–N, and C–O bonds in a one-pot procedure.

Graphical abstract: Palladium-catalyzed tandem reaction of 2-chloroquinoline-3-carbaldehydes and isocyanides

Supplementary files

Article information

Article type
Paper
Submitted
16 Aug 2017
Accepted
09 Nov 2017
First published
09 Nov 2017

Org. Biomol. Chem., 2017,15, 10073-10081

Palladium-catalyzed tandem reaction of 2-chloroquinoline-3-carbaldehydes and isocyanides

M. Shiri, M. Ranjbar, Z. Yasaei, F. Zamanian and B. Notash, Org. Biomol. Chem., 2017, 15, 10073 DOI: 10.1039/C7OB02043K

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