The synthesis of three planar chiral pseudo-gem disubstituted [2.2]paracyclophane-derived P,N-pre-ligands is reported along with preliminary results of their activity in the amination of aryl bromides and chlorides. The pseudo-gem aminophosphines were capable of mediating the coupling reaction at a loading of 1 mol%.
![Graphical abstract: The synthesis of planar chiral pseudo-gem aminophosphine pre-ligands based on [2.2]paracyclophane](/en/Image/Get?imageInfo.ImageType=GA&imageInfo.ImageIdentifier.ManuscriptID=C7OB02393F&imageInfo.ImageIdentifier.Year=2017)
K. P. Jayasundera, T. G. W. Engels, D. J. Lun, M. N. Mungalpara, P. G. Plieger and G. J. Rowlands, Org. Biomol. Chem., 2017, 15, 8975 DOI: 10.1039/C7OB02393F
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