Issue 45, 2017

Efficient dehydrative alkylation of thiols with alcohols catalyzed by alkyl halides

Abstract

Alcohols can be efficiently converted into the useful thioethers by a transition metal- and base-free dehydrative S-alkylation reaction with thiols or disulfides by employing alkyl halides as the effective catalyst. This simple and efficient method is a green and practical way for the preparation of thioethers, as it tolerates a wide range of substrates such as aryl and alkyl thiols, as well as benzylic, allylic, secondary, tertiary, and even the less reactive aliphatic alcohols.

Graphical abstract: Efficient dehydrative alkylation of thiols with alcohols catalyzed by alkyl halides

Supplementary files

Article information

Article type
Paper
Submitted
04 Oct 2017
Accepted
31 Oct 2017
First published
31 Oct 2017

Org. Biomol. Chem., 2017,15, 9638-9642

Efficient dehydrative alkylation of thiols with alcohols catalyzed by alkyl halides

Y. Yang, Z. Ye, X. Zhang, Y. Zhou, X. Ma, H. Cao, H. Li, L. Yu and Q. Xu, Org. Biomol. Chem., 2017, 15, 9638 DOI: 10.1039/C7OB02461D

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