Synthesis of diverse heterocycles via one-pot cascade cross-dehydrogenative-coupling (CDC)/cyclization reaction

Abstract

A cascade Cross-Dehydrogenative-Coupling (CDC)/cyclization methodology has been developed for the synthesis of diverse scaffolds. This method can be successfully employed to prepare various heterocycles including phenanthridines, lactams, lactones and dibenzofurans via a one-pot reaction. Two directing groups were used to enhance the selectivity. Our synthetic strategy exhibits several advantages including using non-prefunctional starting material, less chemical steps and easier purification process. These heterocycle compounds may have a broad utility in the field of medicinal chemistry, materials, etc.