Issue 1, 2017
From the journal:

Organic Chemistry Frontiers

Synthesis of tricyclic 3-hydroxyisoindolin-1-ones via triethylamine-catalyzed domino reactions of electron-deficient alkynes with phthalimidomalonate derivatives†

Li Zhang,a   Beichen Zhang,a   Teng Jiang,a   Tao Lu*a  and  Qingfa Zhou*a  

* Corresponding authors

a State Key Laboratory of Natural Medicines, Department of Organic Chemistry, China Pharmaceutical University, Nanjing, P. R. China
E-mail: zhouqingfa@cpu.edu.cn

Abstract

A triethylamine-catalyzed domino reaction between phthalimidomalonate derivatives and activated alkynes has been developed. This catalytic protocol is applicable to the synthesis of structurally functionalized N-fused tricyclic 3-hydroxyisoindolin-1-ones.

Graphical abstract: Synthesis of tricyclic 3-hydroxyisoindolin-1-ones via triethylamine-catalyzed domino reactions of electron-deficient alkynes with phthalimidomalonate derivatives

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Article information

DOI
https://doi.org/10.1039/C6QO00544F
Article type
Research Article
Submitted
14 Sep 2016
Accepted
22 Oct 2016
First published
25 Oct 2016

Org. Chem. Front., 2017,4, 119-123

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Synthesis of tricyclic 3-hydroxyisoindolin-1-ones via triethylamine-catalyzed domino reactions of electron-deficient alkynes with phthalimidomalonate derivatives

L. Zhang, B. Zhang, T. Jiang, T. Lu and Q. Zhou, Org. Chem. Front., 2017, 4, 119 DOI: 10.1039/C6QO00544F

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