Issue 1, 2017
From the journal:

Organic Chemistry Frontiers

Copper-catalyzed C5-selective thio/selenocyanation of 8-aminoquinolines†

Jichao Chen,a   Tianyu Wang,a   Tong Wang,*ab   Aijun Lin,a   Hequan Yaoa  and  Jinyi Xu*a  

* Corresponding authors

a State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, P. R. China
E-mail: jinyixu@china.com

b Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, 100190 Beijing, P. R. China
E-mail: wangtong@iccas.ac.cn

Abstract

Copper-catalyzed direct C5-position thio/selenocyanation of quinolines using commercially available, inexpensive KSCN/SeCN as the thio/selenocyanation reagent was developed, which had good tolerance toward various aliphatic or aromatic 8-aminoquinoline derivatives. Importantly, the synthetic application of this protocol led to some useful compounds.

Graphical abstract: Copper-catalyzed C5-selective thio/selenocyanation of 8-aminoquinolines

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C6QO00590J
Article type
Research Article
Submitted
28 Sep 2016
Accepted
22 Oct 2016
First published
26 Oct 2016

Org. Chem. Front., 2017,4, 130-134

Permissions

Request permissions

Copper-catalyzed C5-selective thio/selenocyanation of 8-aminoquinolines

J. Chen, T. Wang, T. Wang, A. Lin, H. Yao and J. Xu, Org. Chem. Front., 2017, 4, 130 DOI: 10.1039/C6QO00590J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements