Transition-metal-free electrophilic trifluoromethylthiolation with sodium trifluoromethanesulfinate at room temperature†
Abstract
A transition-metal-free direct trifluoromethylthiolation of indole derivatives under mild conditions has been developed. Commercially available sodium trifluoromethanesulfinate (CF3SO2Na) acts as the trifluoromethylthiolating reagent, which is cheap, stable and easy to handle. The substrate scope of this protocol could also be expanded to pyrroles and enamines.