Issue 2, 2017

Transition-metal-free electrophilic trifluoromethylthiolation with sodium trifluoromethanesulfinate at room temperature

Abstract

A transition-metal-free direct trifluoromethylthiolation of indole derivatives under mild conditions has been developed. Commercially available sodium trifluoromethanesulfinate (CF3SO2Na) acts as the trifluoromethylthiolating reagent, which is cheap, stable and easy to handle. The substrate scope of this protocol could also be expanded to pyrroles and enamines.

Graphical abstract: Transition-metal-free electrophilic trifluoromethylthiolation with sodium trifluoromethanesulfinate at room temperature

Supplementary files

Article information

Article type
Research Article
Submitted
11 Oct 2016
Accepted
25 Nov 2016
First published
29 Nov 2016

Org. Chem. Front., 2017,4, 266-270

Transition-metal-free electrophilic trifluoromethylthiolation with sodium trifluoromethanesulfinate at room temperature

M. Bu, G. Lu and C. Cai, Org. Chem. Front., 2017, 4, 266 DOI: 10.1039/C6QO00622A

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