Issue 2, 2017
From the journal:

Organic Chemistry Frontiers

Efficient synthesis of (S,R)-Bn-Yanphos and Rh/(S,R)-Bn-Yanphos catalyzed asymmetric hydroformylation of vinyl heteroarenes†

Biao Wei,a   Caiyou Chen,a   Cai You,a   Hui Lv*a  and  Xumu Zhang*ab  

* Corresponding authors

a Key Laboratory of Biomedical Polymers of Ministry of Education & College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei 430072, China
E-mail: huilv@whu.edu.cn

b Department of Chemistry, South University of Science and Technology of China, Shenzhen, Guangdong, China
E-mail: zhangxm@sustc.edu.cn

Abstract

A concise and efficient synthesis of (S,R)-Bn-Yanphos on a gram scale has been developed. When (S,R)-Bn-Yanphos was employed in Rh-catalyzed asymmetric hydroformylation of vinyl heteroarenes and allyl-1H-indole, it exhibited excellent catalytic activity, affording chiral heteroaryl aldehydes in good yields with high regio- and enantioselectivities (up to 96% ee).

Graphical abstract: Efficient synthesis of (S,R)-Bn-Yanphos and Rh/(S,R)-Bn-Yanphos catalyzed asymmetric hydroformylation of vinyl heteroarenes

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Article information

DOI
https://doi.org/10.1039/C6QO00641H
Article type
Research Article
Submitted
29 Oct 2016
Accepted
24 Nov 2016
First published
06 Dec 2016

Org. Chem. Front., 2017,4, 288-291

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Efficient synthesis of (S,R)-Bn-Yanphos and Rh/(S,R)-Bn-Yanphos catalyzed asymmetric hydroformylation of vinyl heteroarenes

B. Wei, C. Chen, C. You, H. Lv and X. Zhang, Org. Chem. Front., 2017, 4, 288 DOI: 10.1039/C6QO00641H

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