Rh(iii)-Catalyzed direct C-7 amination of indolines with anthranils

Abstract

An efficient and practical method for the C-7 amination of indolines via Rh(III)-catalyzed C–H activation has been reported. This reaction affords various C-7 aminated indolines in good to excellent yields by using readily available anthranils as the aminating agents. The corresponding indolines with an amino and a carbonyl group together provide an opportunity for the construction and modification of diverse indoles and indolines in the pharmaceutical industry.