An efficient and convenient method of C5-selective halogenation of quinoline derivatives was developed. The reaction proceeds smoothly in water with readily available N-halosuccinimides (NCS, NBS and NIS) as the halogenation reagents. This method features metal-free catalysis, no additional oxidants and additives, broad substrate scope and short reaction time.
J. Chen, T. Wang, Y. Liu, T. Wang, A. Lin, H. Yao and J. Xu, Org. Chem. Front., 2017, 4, 622 DOI: 10.1039/C6QO00765A
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