Issue 6, 2017

Solvent-free ruthenium trichloride-mediated [2 + 2 + 2] cycloaddition of α,ω-diynes and cyanamides: a convenient access to 2-aminopyridines

Abstract

A convenient access to functionalized 2-aminopyridines via a solventless Ru-catalyzed [2 + 2 + 2] cycloaddition reaction of α,ω-diynes and cyanamides is described. This transformation efficiently proceeds in the presence of a stable, easy to handle, and cost-effective RuCl3·nH2O complex, leading to various 2-aminopyridines in good to excellent yields according to an eco-friendly, straightforward approach.

Graphical abstract: Solvent-free ruthenium trichloride-mediated [2 + 2 + 2] cycloaddition of α,ω-diynes and cyanamides: a convenient access to 2-aminopyridines

Supplementary files

Article information

Article type
Research Article
Submitted
20 Jan 2017
Accepted
09 Feb 2017
First published
09 Feb 2017

Org. Chem. Front., 2017,4, 1063-1068

Solvent-free ruthenium trichloride-mediated [2 + 2 + 2] cycloaddition of α,ω-diynes and cyanamides: a convenient access to 2-aminopyridines

F. Ye, M. Haddad, V. Michelet and V. Ratovelomanana-Vidal, Org. Chem. Front., 2017, 4, 1063 DOI: 10.1039/C7QO00058H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements