Metal-free chloroamidation of indoles with sulfonamides and NaClO

Abstract

An efficient and rapid protocol for chloroamidation of indoles with sulfonamides and aqueous NaClO has been developed. The reaction completes in less than half an hour at room temperature without any transition metals. Both indoles and sulfonamides can be easily varied with high functional group tolerance. A variety of structurally diverse 3-chloro-2-amidoindoles are prepared with up to 97% yields.