Iodine-catalyzed cascade annulation of alkynes with sodium arylsulfinates: assembly of 3-sulfenylcoumarin and 3-sulfenylquinolinone derivatives

Abstract

An efficient and versatile iodine-catalyzed electrophilic cyclization has been achieved to afford functionalized 3-sulfenylcoumarin and 3-sulfenylquinolinone derivatives in moderate to good yields from readily available alkynes with sodium arylsulfinates. Moreover, broad substrate scope, excellent functional group compatibility, and high-value products make this protocol practical and attractive, offering potential applications in organic synthesis and medicinal chemistry.