Silver-catalyzed cyclization of nitrones with 2-azetine: a radical approach to 2,3-disubstituted quinolines

Abstract

A silver-catalyzed intermolecular tandem cyclization of nitrones with 2-azetine was developed for the synthesis of 2,3-disubstituted quinolines under mild conditions with good yields. This approach features a C–N bond cleavage of 2-azetine and an N–O bond cleavage of nitrones via a radical pathway. The results of this study provide a new reaction pattern for nitrones and may find applications in the synthesis of other heterocycles.