Issue 12, 2017

Synthesis of substituted oxazoles via Pd-catalyzed tandem oxidative cyclization

Abstract

A novel method for the synthesis of multisubstituted oxazoles by palladium-catalyzed oxidative cyclization of N-acyl enamides has been developed. The reaction employs readily available iodobenzenes and enamides as the starting materials under mild reaction conditions and provides a reliable way to achieve versatile substituted oxazole derivatives.

Graphical abstract: Synthesis of substituted oxazoles via Pd-catalyzed tandem oxidative cyclization

Supplementary files

Article information

Article type
Research Article
Submitted
26 Jun 2017
Accepted
28 Aug 2017
First published
04 Sep 2017

Org. Chem. Front., 2017,4, 2428-2432

Synthesis of substituted oxazoles via Pd-catalyzed tandem oxidative cyclization

W. Zhang, W. Yu, Q. Yan, Z. Liu and Y. Zhang, Org. Chem. Front., 2017, 4, 2428 DOI: 10.1039/C7QO00517B

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