A carbene-catalyzed oxidative reaction for the synthesis of dihydropyran-4-carbonitriles bearing all-carbon quaternary centers was developed. The use of a LiCl additive significantly improved both the reaction efficiency and stereo-selectivities, and the carbonitrile products were obtained in good yields and excellent er values.
Q. Wu, C. Li, W. Wang, H. Wang, D. Pan and P. Zheng, Org. Chem. Front., 2017, 4, 2323 DOI: 10.1039/C7QO00571G
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