Synthesis of dendrobatid alkaloid (+)-167B and (+)-209D and the investigation of diastereoselectivity using DFT calculations

Abstract

The synthesis of dendrobatid alkaloid (+)-167B and (+)-209D has been developed on the basis of the effective preparation of chiral tropinone 7-azabicyclo[3.2.1]octan-6-ol. DFT calculations have been applied to explain the observed diastereoselectivity.