AgSCF3-mediated trifluoromethylthiolation of α,α-diaryl allylic alcohols via radical neophyl rearrangement

Abstract

A novel example of AgSCF₃-mediated oxidative radical trifluoromethylthiolation of α,α-diaryl allylic alcohols is presented, producing various α-aryl-β-trifluoromethylthiolated carbonyl ketones via radical neophyl rearrangement under mild conditions. This protocol involves formation of C(Ar)–C(sp³) and C(sp³)–S bonds in one step and tolerates a wide range of symmetrical and nonsymmetrical α,α-diaryl allylic alcohols.