Issue 6, 2017, Issue in Progress

Two rare meroterpenoidal rotamers from Ganoderma applanatum

Abstract

Applanatumols Z3 (1) and Z4 (2), two novel natural product hybrids consisting of a meroterpenoid and a glycerol and three known compounds (3–5) were isolated from the fruiting bodies of the fungus Ganoderma applanatum. Their structures were elucidated by means of spectroscopic methods, ECD and 13C NMR calculations. It is of particular interest that 1 and 2 are rare separable conformers. Racemic 1 and 2 were further separated by chiral HPLC to afford their respective enantiomers, whose biological activities were evaluated against JAK3 and DDR1 kinases.

Graphical abstract: Two rare meroterpenoidal rotamers from Ganoderma applanatum

Supplementary files

Article information

Article type
Paper
Submitted
09 Nov 2016
Accepted
29 Nov 2016
First published
13 Jan 2017
This article is Open Access
Creative Commons BY license

RSC Adv., 2017,7, 3413-3418

Two rare meroterpenoidal rotamers from Ganoderma applanatum

Q. Luo, Z. Tu and Y. Cheng, RSC Adv., 2017, 7, 3413 DOI: 10.1039/C6RA26572C

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