Palladium-catalyzed three-component tandem cyclization of buta-2,3-dien-1-ol, aryl iodides, and imines: an efficient protocol for the synthesis of oxazolidine derivatives

Abstract

An efficient three-component tandem cyclization reaction for the synthesis of highly substituted oxazolidines was achieved through the Pd⁰-catalyzed cyclization of buta-2,3-dien-1-ol with aryl iodides and imines. A range of R¹ and R² functional groups is well-tolerated while affording cyclization products in moderate yields and with moderate to high diastereoselectivities.