Issue 31, 2017

Highly efficient one-pot tandem Friedlander annulation and chemo-selective Csp3–H functionalization under calcium catalysis

Abstract

A highly efficient and regioselective Friedlander synthesis of 2-methyl-3-acyl quinolines is described, which occurs under solvent-free conditions and employs calcium triflate as a sustainable catalyst. For the first time in the literature, these 2-methyl-3-acyl quinolines undergo an in situ chemoselective Csp3–H functionalization to furnish structurally enriched quinoline heterocycles in high yields and with atom and step economy.

Graphical abstract: Highly efficient one-pot tandem Friedlander annulation and chemo-selective Csp3–H functionalization under calcium catalysis

Supplementary files

Article information

Article type
Paper
Submitted
24 Dec 2016
Accepted
13 Mar 2017
First published
28 Mar 2017
This article is Open Access
Creative Commons BY license

RSC Adv., 2017,7, 18874-18882

Highly efficient one-pot tandem Friedlander annulation and chemo-selective Csp3–H functionalization under calcium catalysis

G. Singh and S. Yaragorla, RSC Adv., 2017, 7, 18874 DOI: 10.1039/C6RA28642A

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