Preparation of [18F]-NHC-BF3 conjugates and their applications in PET imaging

Kantapat Chansaenpak; Mengzhe Wang; Hui Wang; Benjamin C. Giglio; François P. Gabbaï; Zhanhong Wu; Zibo Li

doi:10.1039/C6RA28806E

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Preparation of [¹⁸F]-NHC-BF₃ conjugates and their applications in PET imaging†

Kantapat Chansaenpak,‡^ac Mengzhe Wang,‡^a Hui Wang,^a Benjamin C. Giglio,^a François P. Gabbaï,

^b Zhanhong Wu^a and Zibo Li

*^a

Author affiliations

* Corresponding authors

^a Biomedical Research Imaging Center, Department of Radiology, University of North Carolina, Chapel Hill, North Carolina, USA 27514
E-mail: ziboli@med.unc.edu

^b Department of Chemistry, Texas A&M University, College Station, Texas, USA 77843

^c National Nanotechnology Center (NANOTEC), National Science and Technology Development Agency (NSTDA), 111 Thailand Science Park, Pathum Thani, Thailand 12120

Abstract

N-Heterocyclic carbene boron trifluoride (NHC-BF₃) conjugates were successfully radiofluorinated by SnCl₄-promoted ¹⁸F–¹⁹F isotopic exchange reaction in one labelling step. This method afforded in vivo stable PET agents that efficiently bound to targeted tumours yielding PET images with good tumour-to-background contrast.

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Article information

DOI: https://doi.org/10.1039/C6RA28806E
Article type: Paper
Submitted: 29 Dec 2016
Accepted: 14 Mar 2017
First published: 22 Mar 2017
This article is Open Access

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RSC Adv., 2017,7, 17748-17751

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Preparation of [¹⁸F]-NHC-BF₃ conjugates and their applications in PET imaging

K. Chansaenpak, M. Wang, H. Wang, B. C. Giglio, F. P. Gabbaï, Z. Wu and Z. Li, RSC Adv., 2017, 7, 17748 DOI: 10.1039/C6RA28806E

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