Matrix-assisted diffusion-ordered NMR spectroscopy with an invisible, tuneable matrix

Abstract

Mixtures of species of similar sizes can be analysed with ¹H NMR using diffusion-ordered spectroscopy (DOSY), by adding a co-solute with which different analytes interact to different extents (“matrix-assisted DOSY”). A matrix containing aqueous perfluorooctanoate micelles has the dual advantages of invisibility to ¹H NMR, and interactions tuneable by adjusting the pH.