Issue 43, 2017, Issue in Progress

Maghemite-containing PLGA–PEG-based polymeric nanoparticles for siRNA delivery: toxicity and silencing evaluation

Abstract

Gene therapy based on small interfering RNA (siRNA) has emerged as an exciting new therapeutic approach. In this work, incorporation of PEI into poly(D,L-lactide-co-glycolide)-poly(ethylene glycol) (PLGA-b-PEG) particles has been shown to be quite effective in the development of corresponding gene delivery systems, and encapsulation of magnetic nanoparticles as an MRI contrast agent, resulted in unique theranostic nanoparticles.

Graphical abstract: Maghemite-containing PLGA–PEG-based polymeric nanoparticles for siRNA delivery: toxicity and silencing evaluation

Article information

Article type
Paper
Submitted
12 Jan 2017
Accepted
15 May 2017
First published
19 May 2017
This article is Open Access
Creative Commons BY license

RSC Adv., 2017,7, 26912-26920

Maghemite-containing PLGA–PEG-based polymeric nanoparticles for siRNA delivery: toxicity and silencing evaluation

E. Lellouche, E. Locatelli, L. L. Israel, M. Naddaka, E. Kurlander, S. Michaeli, J. Lellouche and M. C. Franchini, RSC Adv., 2017, 7, 26912 DOI: 10.1039/C7RA00517B

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