Issue 25, 2017
From the journal:

RSC Advances

A poly(amidoamine) dendrimer-based drug carrier for delivering DOX to gliomas cells†

Yan Li,ab   Hai He,b   Wanliang Lu*c  and  Xinru Jia ORCID logo *b  

* Corresponding authors

a College of Materials Science and Engineering, Hebei University of Engineering, Handan 056038, China

b Beijing National Laboratory for Molecular Sciences, Key Laboratory of Polymer Chemistry and Physics of the Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China
E-mail: xrjia@pku.edu.cn

c State Key Laboratory of Natural and Biomimetic Drugs and School of Pharmaceutical Science, Peking University, Beijing, China
E-mail: luwl@bjmu.edu.cn

Abstract

A drug delivery carrier G4–FA–PEG with PEG and FA modified on the periphery of G4.0 poly(amidoamine) (PAMAM) dendrimer was synthesized, and doxorubicin (DOX) was encapsulated in the interior. The in vitro cytotoxicity and cellular uptake in gliomas cells were both enhanced via a FR-mediated endocytosis pathway.

Graphical abstract: A poly(amidoamine) dendrimer-based drug carrier for delivering DOX to gliomas cells

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Article information

DOI
https://doi.org/10.1039/C7RA00713B
Article type
Paper
Submitted
17 Jan 2017
Accepted
03 Mar 2017
First published
08 Mar 2017
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2017,7, 15475-15481

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A poly(amidoamine) dendrimer-based drug carrier for delivering DOX to gliomas cells

Y. Li, H. He, W. Lu and X. Jia, RSC Adv., 2017, 7, 15475 DOI: 10.1039/C7RA00713B

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