Nano-mechanical in-process monitoring of antimicrobial poration in model phospholipid bilayers

Andrea Valsesia; Patrizia Iavicoli; Helen Lewis; Cloé Desmet; Dora Mehn; Luigi Calzolai; Pascal Colpo; François Rossi; Maxim G. Ryadnov

doi:10.1039/C7RA01274H

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Nano-mechanical in-process monitoring of antimicrobial poration in model phospholipid bilayers†

Andrea Valsesia,

*^a Patrizia Iavicoli,^a Helen Lewis,^b Cloé Desmet,^a Dora Mehn,^a Luigi Calzolai,^a Pascal Colpo,^a François Rossi^a and Maxim G. Ryadnov*^b

Author affiliations

* Corresponding authors

^a European Commission – Directorate General Joint Research Centre Directorate F – Health, Consumers and Reference Materials – Consumer Products Safety, Via Fermi 2749 TP-125, 21027 Ispra, VA, Italy
E-mail: andrea.valsesia@ec.europa.eu

^b National Physical Laboratory, Teddington TW11 0LW, UK
E-mail: max.ryadnov@npl.co.uk

Abstract

Nanomechanical monitoring of known mechanisms of membrane poration mediated by host defense peptides is reported. Quartz Crystal Microbalance with Dissipation monitoring used to probe the process of antimicrobial poration in model phospholipid bilayers offers a straightforward method for mechanically differential kinetic measurements of membrane-mediated antimicrobial effects in situ.

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Article information

DOI: https://doi.org/10.1039/C7RA01274H
Article type: Paper
Submitted: 30 Jan 2017
Accepted: 22 Mar 2017
First published: 30 Mar 2017
This article is Open Access

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RSC Adv., 2017,7, 19081-19084

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Nano-mechanical in-process monitoring of antimicrobial poration in model phospholipid bilayers

A. Valsesia, P. Iavicoli, H. Lewis, C. Desmet, D. Mehn, L. Calzolai, P. Colpo, F. Rossi and M. G. Ryadnov, RSC Adv., 2017, 7, 19081 DOI: 10.1039/C7RA01274H

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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Nano-mechanical in-process monitoring of antimicrobial poration in model phospholipid bilayers†

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