Issue 64, 2017

Hydrophobic tagging-mediated degradation of Alzheimer's disease related Tau

Abstract

Tau reduction is a favorable strategy for Alzheimer's disease (AD) treatment. In this work, we designed and synthesized a hydrophobic tag conjugated peptide (HyT-Tau-CPP) to selectively promote the degradation of Tau. HyT-Tau-CPP could potently lower the Tau level in a concentration- and time-dependent manner. Furthermore, HyT-Tau-CPP could also reduce the level of Tau in the brain of AD mouse models. Therefore, Tau reduction by HyT-Tau-CPP may become a potential therapeutic strategy in the treatment for AD.

Graphical abstract: Hydrophobic tagging-mediated degradation of Alzheimer's disease related Tau

Supplementary files

Article information

Article type
Paper
Submitted
11 May 2017
Accepted
04 Aug 2017
First published
18 Aug 2017
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2017,7, 40362-40366

Hydrophobic tagging-mediated degradation of Alzheimer's disease related Tau

N. Gao, T. Chu, Q. Li, Y. Lim, T. Qiu, M. Ma, Z. Hu, X. Yang, Y. Chen, Y. Zhao and Y. Li, RSC Adv., 2017, 7, 40362 DOI: 10.1039/C7RA05347A

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