A novel application of the Staudinger ligation to access neutral cyclic di-nucleotide analog precursors via a divergent method

M. H. Fletcher; C. E. Burns-Lynch; K. W. Knouse; L. T. Abraham; C. W. DeBrosse; W. M. Wuest

doi:10.1039/C7RA06045A

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A novel application of the Staudinger ligation to access neutral cyclic di-nucleotide analog precursors via a divergent method†‡

M. H. Fletcher,^a C. E. Burns-Lynch,^a K. W. Knouse,

^a L. T. Abraham,^a C. W. DeBrosse^a and W. M. Wuest

*^b

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* Corresponding authors

^a Department of Chemistry, Temple University, Philadelphia, PA 19122, USA

^b Department of Chemistry, Emory University, Atlanta, GA 30322, USA
E-mail: wwuest@emory.edu

Abstract

Our efforts to develop a scalable and divergent synthesis of cyclic di-nucleotide analog precursors have resulted in (1) an orthogonally protected di-amino carbohydrate as well as (2) the novel application of the Staudinger ligation to provide medium-sized macrocycles featuring carbamate or urea linkages.

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Article information

DOI: https://doi.org/10.1039/C7RA06045A
Article type: Paper
Submitted: 30 May 2017
Accepted: 01 Jun 2017
First published: 07 Jun 2017
This article is Open Access

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RSC Adv., 2017,7, 29835-29838

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A novel application of the Staudinger ligation to access neutral cyclic di-nucleotide analog precursors via a divergent method

M. H. Fletcher, C. E. Burns-Lynch, K. W. Knouse, L. T. Abraham, C. W. DeBrosse and W. M. Wuest, RSC Adv., 2017, 7, 29835 DOI: 10.1039/C7RA06045A

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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A novel application of the Staudinger ligation to access neutral cyclic di-nucleotide analog precursors via a divergent method†‡

Abstract

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A novel application of the Staudinger ligation to access neutral cyclic di-nucleotide analog precursors via a divergent method

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