Bimetallic copper and zinc-catalyzed oxidative cycloaddition of 3-aminopyridazines and nitriles: a direct synthesis of 1,2,4-triazolo[1,5-b]pyridazines via C–N and N–N bond-forming process

Abstract

One-pot formation of the 1,2,4-triazolo[1,5-b]pyridazine nucleus and its derivatives is presented in this manuscript, in which the desired targets are offered easily via cooperative Cu(I) and Zn(II)-catalyzed tandem C–N addition and subsequent I₂/KI-mediated intramolecular oxidative N–N bond formation.