Improved shellac mediated nanoscale application drug release effect in a gastric-site drug delivery system

Abstract

The development of biocompatible nanocomposites for biomedical applications such as drug release has attracted increasing attention in recent years. Shellac/sodium shellac nanofibers and nanoparticles were produced for drug delivery applications. Ketoprofen was loaded on the drug delivery system (DDS), and three schemes based on shellac/sodium shellac were chosen. The biocompatibility and nontoxicity of shellac and the promising results of the nanofibers and nanoparticles highlighted their challenging potential for controlled drug delivery applications. A significant increase of drug release rate can be observed at the gastric site. The prepared drug-loaded nanofibers and nanoparticles were characterized by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD). The results show that the above-mentioned drug delivery system is able to support high-efficiency encapsulation. A new drug delivery system was designed and studied through shellac and sodium shellac. The application scope of shellac to DDSs is extended.