Bifunctional N-heterocyclic carbene ligands for Cu-catalyzed direct C–H carboxylation with CO2

Abstract

Diethylene glycol-functionalized imidazo[1,5-a]pyridin-3-ylidenes (DEG-ImPy) have been developed as bifunctional N-heterocyclic carbene ligands. The DEG-ImPy Cu(I) complexes efficiently catalyzed the direct C–H carboxylation of benzoxazole with CO₂, showing higher isolated yields than those with the N,N′-(2,6-diisopropylphenyl)imidazolylidene Cu catalyst.