Issue 88, 2017, Issue in Progress

Ent-abietane diterpenoids and their probable biogenetic precursors from the roots of Euphorbia fischeriana

Abstract

Five new ent-abietane diterpenoids (1–5), along with nine known analogues (6–14), were isolated from the roots of Euphorbia fischeriana. Their structures and absolute configurations were determined by the analysis of extensive spectroscopic data (UV, IR, HRESIMS, NMR) and the comparison of the experimental and calculated electronic circular dichroism (ECD). Among the isolates, it's notable that the ent-abietane diterpenoids bearing an additional five-membered lactone ring might be derived from the proposed precursors of fischeriabietane B (2) and C (3), and their plausible biosynthetic relationship was detailed discussed. All the isolates were evaluated for cytotoxicity against three human cancer cell lines (Panc-28, Bel-7402, and HT-29), 2 and 3 exhibited moderate cytotoxicity.

Graphical abstract: Ent-abietane diterpenoids and their probable biogenetic precursors from the roots of Euphorbia fischeriana

Supplementary files

Article information

Article type
Paper
Submitted
31 Oct 2017
Accepted
24 Nov 2017
First published
08 Dec 2017
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2017,7, 55859-55865

Ent-abietane diterpenoids and their probable biogenetic precursors from the roots of Euphorbia fischeriana

J. Zhang, J. He, X. Wang, Y. Shi, N. Zhang, B. Ma, W. Zhang and J. Xu, RSC Adv., 2017, 7, 55859 DOI: 10.1039/C7RA11982H

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