Issue 3, 2017
From the journal:

Journal of Materials Chemistry B

The application of a G-quadruplex based assay with an iridium(iii) complex to arsenic ion detection and its utilization in a microfluidic chip†

Sheng Lin,a   Wanhe Wang,a   Chong Hu,a   Guanjun Yang,b   Chung-Nga Ko,a   Kangning Ren,*a   Chung-Hang Leung*b  and  Dik-Lung Ma ORCID logo *a  

* Corresponding authors

a Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China
E-mail: edmondma@hkbu.edu.hk, kangningren@hkbu.edu.hk

b State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China
E-mail: duncanleung@umac.mo

Abstract

In this work, the iridium(III) complex 1 was synthesized and employed in constructing an assay which is based on a G-quadruplex for detecting arsenic ions in aqueous solution. The assay achieved a detection limit of 7.6 nM (ca. 0.57 μg L−1) and showed high selectivity towards arsenic ions over other metal ions. Additionally, the assay could function in natural water and a simple microfluidic chip was used to investigate the potential of this platform for real-time detection.

Graphical abstract: The application of a G-quadruplex based assay with an iridium(iii) complex to arsenic ion detection and its utilization in a microfluidic chip

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Article information

DOI
https://doi.org/10.1039/C6TB02656G
Article type
Paper
Submitted
11 Oct 2016
Accepted
07 Dec 2016
First published
08 Dec 2016

J. Mater. Chem. B, 2017,5, 479-484

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The application of a G-quadruplex based assay with an iridium(III) complex to arsenic ion detection and its utilization in a microfluidic chip

S. Lin, W. Wang, C. Hu, G. Yang, C. Ko, K. Ren, C. Leung and D. Ma, J. Mater. Chem. B, 2017, 5, 479 DOI: 10.1039/C6TB02656G

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