A promising dual mode SPECT/CT imaging platform based on 99mTc-labeled multifunctional dendrimer-entrapped gold nanoparticles

Abstract

Multifunctional ^99mTc-labeled dendrimer-entrapped gold nanoparticles (^99mTc-Au DENPs) were designed and synthesized. Our results show that the type of surface groups (acetyl or hydroxyl) significantly impact the biodistribution profile of the ^99mTc-Au DENPs, thereby allowing for preferential SPECT/CT imaging of different organs.