Synergistic and targeted drug delivery based on nano-CeO2 capped with galactose functionalized pillar[5]arene via host–guest interactions

Xiaowen Wu; Ying Zhang; Yuchao Lu; Shuang Pang; Kui Yang; Zhimin Tian; Yuxin Pei; Yongquan Qu; Feng Wang; Zhichao Pei

doi:10.1039/C7TB00752C

Synergistic and targeted drug delivery based on nano-CeO₂ capped with galactose functionalized pillar[5]arene via host–guest interactions†

Xiaowen Wu,^a Ying Zhang,^a Yuchao Lu,^a Shuang Pang,^a Kui Yang,^a Zhimin Tian,^b Yuxin Pei,*^a Yongquan Qu,^b Feng Wang^a and Zhichao Pei

*^a

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* Corresponding authors

^a Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry and Pharmacy, Northwest A&F University, Yangling, 712100 Shaanxi, P. R. China
E-mail: peiyx@nwafu.edu.cn, peizc@nwafu.edu.cn

^b Center for Applied Chemical Research, Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an, China

Abstract

A smart drug delivery system based on porous CeO₂ nano-rods (CeONRs) capped with galactose functionalized pillar[5]arene via host–guest interactions has been constructed, which showed GSH-responsiveness, synergism with anticancer drugs and cancer targeting ability resulting from its disulphide unit, ceria properties and galactose units, respectively.

Journal of Materials Chemistry B

Synergistic and targeted drug delivery based on nano-CeO₂ capped with galactose functionalized pillar[5]arene via host–guest interactions†

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Synergistic and targeted drug delivery based on nano-CeO₂ capped with galactose functionalized pillar[5]arene via host–guest interactions

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Journal of Materials Chemistry B