Issue 35, 2017

Gold-stabilized carboxymethyl dextran nanoparticles for image-guided photodynamic therapy of cancer

Abstract

Photodynamic therapy (PDT) has been extensively investigated to treat cancer since it induces cell death through the activation of photosensitizers by light. However, its success has been hampered by the insufficient selectivity of photosensitizers to tumor tissues. In an attempt to increase the therapeutic efficacy of PDT by targeting the photosensitizer specifically to the tumor site, we prepared chlorin e6 (Ce6)-loaded gold-stabilized carboxymethyl dextran nanoparticles (Ce6-GS-CNPs). Ce6-GS-CNPs possessed highly stable nanostructures and no significant change was observed in their particle size in the presence of serum for 6 days. When Ce6-GS-CNPs were intravenously injected into tumor-bearing mice, they exhibited prolonged circulation in the body and gradually accumulated in the tumor tissue. Under laser irradiation of the tumor site which could be recognized by the near-infrared fluorescence imaging system, Ce6-GS-CNPs effectively suppressed tumor growth. Overall, Ce6-GS-CNPs might have potential as nanomedicine for image-guided photodynamic cancer therapy.

Graphical abstract: Gold-stabilized carboxymethyl dextran nanoparticles for image-guided photodynamic therapy of cancer

Supplementary files

Article information

Article type
Paper
Submitted
21 Apr 2017
Accepted
01 Aug 2017
First published
03 Aug 2017

J. Mater. Chem. B, 2017,5, 7319-7327

Gold-stabilized carboxymethyl dextran nanoparticles for image-guided photodynamic therapy of cancer

M. Lee, H. Lee, N. Vijayakameswara Rao, H. S. Han, S. Jeon, J. Jeon, S. Lee, S. Kwon, Y. D. Suh and J. H. Park, J. Mater. Chem. B, 2017, 5, 7319 DOI: 10.1039/C7TB01099K

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements