Issue 33, 2017

Au–Mesoporous silica nanoparticles gated with disulfide-linked oligo(ethylene glycol) chains for tunable cargo delivery mediated by an integrated enzymatic control unit

Abstract

We report a delivery system based on Au–mesoporous silica (MS) nanoparticles functionalized with acetylcholinesterase on the Au face as a control unit and with disulfide-containing oligo(ethylene glycol) chains on the MS face as caps. The control unit handles the chemical information in the environment (the presence of acetylthiocholine or enzyme inhibitors) that results in a tuned cargo delivery from the nanocarrier. The nanodevice displayed an enhanced cargo delivery in cancer cells (safranin O and doxorubicin) in the presence of acetylthiocholine.

Graphical abstract: Au–Mesoporous silica nanoparticles gated with disulfide-linked oligo(ethylene glycol) chains for tunable cargo delivery mediated by an integrated enzymatic control unit

Supplementary files

Article information

Article type
Communication
Submitted
31 Jul 2017
Accepted
05 Aug 2017
First published
07 Aug 2017

J. Mater. Chem. B, 2017,5, 6734-6739

Au–Mesoporous silica nanoparticles gated with disulfide-linked oligo(ethylene glycol) chains for tunable cargo delivery mediated by an integrated enzymatic control unit

A. Llopis-Lorente, B. de Luis, A. García-Fernández, P. Díez, A. Sánchez, M. Dolores Marcos, R. Villalonga, R. Martínez-Máñez and F. Sancenón, J. Mater. Chem. B, 2017, 5, 6734 DOI: 10.1039/C7TB02045G

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