One-step synthesis of an antibacterial and pro-healing wound dressing that can treat wound infections

Abstract

Preventing bacterial contamination, treating wound infections and promoting wound healing have been major challenges in wound care management. In this work, a novel wound dressing based on a zwitterionic polycarboxybetaine (PCB) hydrogel and antibacterial silver nanoparticles (AgNPs) was developed via a one-step method for the efficient treatment of infected wounds. The PCB–AgNP hydrogel exhibits effective antibacterial ability against both Gram positive bacteria (Saphylococcus aureus) and Gram negative bacteria (Escherichia coli). Furthermore, in a murine model, the PCB–AgNP hydrogel is found to efficiently treat S. aureus infection and accelerate cutaneous wound healing. After a two-week healing process, histological tests indicate that it can promote the reconstruction of intact epidermis, which is much faster than those treated with a commercial wound dressing (Duoderm® film). This new bifunctional wound dressing provides new opportunities for highly efficient skin wound care and management.