Issue 23, 2018
From the journal:

Analyst

Imaging nucleus viscosity and G-quadruplex DNA in living cells using a nucleus-targeting two-photon fluorescent probe†

Wan Sun,a   Jing-Xue Cui,a   Le-Le Ma,a   Zhong-Lin Lu, ORCID logo *a   Bing Gong,a   Lan He*b  and  Ruibing Wang ORCID logo *c  

* Corresponding authors

a Key Laboratory of Radiopharmaceuticals, Ministry of Education, College of Chemistry, Beijing Normal University, Xinjiekouwai Street 19, Beijing 100875, China
E-mail: luzl@bnu.edu.cn

b National Institute for Food and Drug Control, Beijing, China
E-mail: helan1961@aliyun.com

c State Key Laboratory of Quality Research in Chinese Medicine, and Institute of Chinese Medical Sciences, University of Macau, Taipa, Macau, China
E-mail: rwang@umac.mo

Abstract

A two-photon fluorescent probe, TP-2Bz, was designed and synthesized and it exhibited good targeting capabilities toward cell nuclei. In particular, TP-2Bz demonstrated a high selectivity to both G-quadruplex DNA and viscosity inside the nucleus with significant ratiometric enhancement in fluorescence, providing a specific, versatile imaging tool for analyzing the viscosity and G-quadruplex DNA in living cells.

Graphical abstract: Imaging nucleus viscosity and G-quadruplex DNA in living cells using a nucleus-targeting two-photon fluorescent probe

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Supplementary files

Article information

DOI
https://doi.org/10.1039/C8AN01643G
Article type
Paper
Submitted
24 Aug 2018
Accepted
04 Oct 2018
First published
10 Oct 2018

Analyst, 2018,143, 5799-5804

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Imaging nucleus viscosity and G-quadruplex DNA in living cells using a nucleus-targeting two-photon fluorescent probe

W. Sun, J. Cui, L. Ma, Z. Lu, B. Gong, L. He and R. Wang, Analyst, 2018, 143, 5799 DOI: 10.1039/C8AN01643G

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