Towards establishing a minimal nanoparticle concentration for applications involving surface enhanced spatially offset resonance Raman spectroscopy (SESORRS) in vivo

Fay Nicolson; Lauren E. Jamieson; Samuel Mabbott; Konstantinos Plakas; Neil C. Shand; Michael R. Detty; Duncan Graham; Karen Faulds

doi:10.1039/C8AN01860J

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Towards establishing a minimal nanoparticle concentration for applications involving surface enhanced spatially offset resonance Raman spectroscopy (SESORRS) in vivo†

Fay Nicolson,

^a Lauren E. Jamieson,

^a Samuel Mabbott,

^a Konstantinos Plakas,

^b Neil C. Shand,

^c Michael R. Detty,

^b Duncan Graham

^a and Karen Faulds

*^a

Author affiliations

* Corresponding authors

^a Department of Pure and Applied Chemistry, Technology and Innovation Centre, University of Strathclyde, 99 George Street, Glasgow G1 1RD, UK
E-mail: karen.faulds@strath.ac.uk

^b Department of Chemistry, University at Buffalo, The State University of New York, New York 14260, USA

^c DSTL, Porton Down, Salisbury, UK

Abstract

Resonant chalcogenpyrylium nanotags demonstrate an exceptional surface enhanced Raman scattering (SERS) performance for use in SORS applications. Using surface enhanced spatially offset Raman spectroscopy (SESORS), nanotags modified with a chalcogenpyrylium dye were observed at concentrations as low as 1 pM through 5 mm of tissue. Calculated limits of detection suggest that these SERS nanotags can be detected at 104 fM using surface enhanced spatially offset resonance Raman scattering (SESORRS) demonstrating their potential for in vivo applications.

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Article information

DOI: https://doi.org/10.1039/C8AN01860J
Article type: Communication
Submitted: 27 Sep 2018
Accepted: 11 Oct 2018
First published: 11 Oct 2018

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Analyst, 2018,143, 5358-5363

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Towards establishing a minimal nanoparticle concentration for applications involving surface enhanced spatially offset resonance Raman spectroscopy (SESORRS) in vivo

F. Nicolson, L. E. Jamieson, S. Mabbott, K. Plakas, N. C. Shand, M. R. Detty, D. Graham and K. Faulds, Analyst, 2018, 143, 5358 DOI: 10.1039/C8AN01860J

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Towards establishing a minimal nanoparticle concentration for applications involving surface enhanced spatially offset resonance Raman spectroscopy (SESORRS) in vivo†

Abstract

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