Coordination-driven self-assembly of a Pt(IV) prodrug-conjugated supramolecular hexagon

Zhizhou Yue; Han Wang; Yiming Li; Yi Qin; Lin Xu; David J. Bowers; Mahinda Gangoda; Xiaopeng Li; Hai-Bo Yang; Yao-Rong Zheng

doi:10.1039/C7CC07622C

Coordination-driven self-assembly of a Pt(iv) prodrug-conjugated supramolecular hexagon†

Zhizhou Yue,‡^a Han Wang,‡^a Yiming Li,^b Yi Qin,^c Lin Xu,^c David J. Bowers,^a Mahinda Gangoda,^a Xiaopeng Li,^b Hai-Bo Yang^c and Yao-Rong Zheng

*^a

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^a Department of Chemistry and Biochemistry, Kent State University, 224 Williams Hall, Kent, Ohio 44242, USA
E-mail: yzheng7@kent.edu

^b Department of Chemistry, CHE 205, University of South Florida, 4202 East Fowler Ave, Tampa, Florida 33620, USA

^c Shanghai Key Laboratory of Green Chemistry and Chemical Processes, Department of Chemistry, East China Normal University, 3663 North Zhongshan Road, Shanghai 200062, People's Republic of China

Abstract

This article presents a new strategy to engage coordination-driven self-assembly for platinum drug delivery. The self-assembled supramolecular hexagon is conjugated with three equivalents of Pt(IV) prodrugs and displays a superior therapeutic index compared to cisplatin against a panel of human cancer cell lines.

Chemical Communications

Coordination-driven self-assembly of a Pt(iv) prodrug-conjugated supramolecular hexagon†

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Coordination-driven self-assembly of a Pt(IV) prodrug-conjugated supramolecular hexagon

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