Issue 1, 2018
From the journal:

Chemical Communications

Photoresponsive spherical nucleic acid: spatiotemporal control of the assembly circuit and intracellular microRNA release†

Xiang Zhou,‡a   Hui Li,‡ab   Miao He,a   Xue Yin,a   Dongbao Yao,a   Shiyan Xiaoa  and  Haojun Liang ORCID logo *ac  

* Corresponding authors

a CAS Key Laboratory of Soft Matter Chemistry, Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei, Anhui 230026, China
E-mail: hjliang@ustc.edu.cn

b Department of Biology and Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong, China

c Collaborative Innovation Center of Chemistry for Energy Materials, Hefei National Laboratory for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei, Anhui 230026, China

Abstract

Herein, we designed and prepared a photoresponsive spherical nucleic acid (SNA) conjugate by inserting a photocleavable linker into the recognition sequence of SNA which can block the reactivity of the system temporally until specific UV light (∼365 nm) is introduced. The photoresponsive SNA realizes temporal regulation of a self-assembly reaction circuit and spatial selectivity of microRNA release in a cell population, respectively.

Graphical abstract: Photoresponsive spherical nucleic acid: spatiotemporal control of the assembly circuit and intracellular microRNA release

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Article information

DOI
https://doi.org/10.1039/C7CC07932J
Article type
Communication
Submitted
13 Oct 2017
Accepted
28 Nov 2017
First published
28 Nov 2017

Chem. Commun., 2018,54, 106-109

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Photoresponsive spherical nucleic acid: spatiotemporal control of the assembly circuit and intracellular microRNA release

X. Zhou, H. Li, M. He, X. Yin, D. Yao, S. Xiao and H. Liang, Chem. Commun., 2018, 54, 106 DOI: 10.1039/C7CC07932J

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