Synergistic effects of stellated fibrous mesoporous silica and synthetic dsRNA analogues for cancer immunotherapy

Xiupeng Wang; Xia Li; Atsuo Ito; Yu Sogo; Yohei Watanabe; Kaoru Hashimoto; Atsushi Yamazaki; Tadao Ohno; Noriko M. Tsuji

doi:10.1039/C7CC08222C

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Synergistic effects of stellated fibrous mesoporous silica and synthetic dsRNA analogues for cancer immunotherapy†

Xiupeng Wang,

*^a Xia Li,

^a Atsuo Ito,^a Yu Sogo,^a Yohei Watanabe,^b Kaoru Hashimoto,^c Atsushi Yamazaki,

^c Tadao Ohno

^d and Noriko M. Tsuji

Author affiliations

* Corresponding authors

^a Health Research Institute, Department of Life Science and Biotechnology, National Institute of Advanced Industrial Science and Technology (AIST), Central 6, 1-1-1 Higashi, Tsukuba, Ibaraki 305-8566, Japan
E-mail: xp-wang@aist.go.jp

^b Biomedical Research Institute, Department of Life Science and Biotechnology, National Institute of Advanced Industrial Science and Technology (AIST), Central 6, 1-1-1 Higashi, Tsukuba, Ibaraki 305-8566, Japan

^c Department of Resources and Environmental Engineering, Waseda University, Shinjuku-ku, Tokyo 169-8555, Japan

^d School of Life Dentistry at Tokyo, The Nippon Dental University, Fujimi, Chiyoda-ku, Tokyo 102-0071, Japan

Abstract

Stellated fibrous mesoporous silica nanospheres significantly improve the cellular uptake of cancer antigen and the maturation of bone marrow derived dendritic cells in vitro. Moreover, the combination of poly(I:C) with stellated fibrous MS nanospheres markedly decreases the necessary dose of poly(I:C) for anti-tumor immunity, and thus opens new opportunities for the future clinical application of poly(I:C) in cancer immunotherapy.

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Article information

DOI: https://doi.org/10.1039/C7CC08222C
Article type: Communication
Submitted: 25 Oct 2017
Accepted: 03 Jan 2018
First published: 03 Jan 2018

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Chem. Commun., 2018,54, 1057-1060

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Synergistic effects of stellated fibrous mesoporous silica and synthetic dsRNA analogues for cancer immunotherapy

X. Wang, X. Li, A. Ito, Y. Sogo, Y. Watanabe, K. Hashimoto, A. Yamazaki, T. Ohno and N. M. Tsuji, Chem. Commun., 2018, 54, 1057 DOI: 10.1039/C7CC08222C

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Chemical Communications

Synergistic effects of stellated fibrous mesoporous silica and synthetic dsRNA analogues for cancer immunotherapy†

Abstract

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Synergistic effects of stellated fibrous mesoporous silica and synthetic dsRNA analogues for cancer immunotherapy

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