Issue 10, 2018

Manganese/cobalt-catalyzed oxidative C(sp3)–H/C(sp3)–H coupling: a route to α-tertiary β-arylethylamines

Abstract

Reported herein is an oxidative coupling reaction of an α-C(sp3)–H bond of amine with a benzylic C(sp3)–H bond through Mn or Co catalysis to provide diverse collections of α-tertiary β-arylethylamines. This protocol features an easily installed and removable coordinating activation group, a wide scope of substrates, low-cost metal catalysts, easily available starting materials and synthetic simplicity.

Graphical abstract: Manganese/cobalt-catalyzed oxidative C(sp3)–H/C(sp3)–H coupling: a route to α-tertiary β-arylethylamines

Supplementary files

Article information

Article type
Communication
Submitted
05 Nov 2017
Accepted
08 Jan 2018
First published
08 Jan 2018

Chem. Commun., 2018,54, 1221-1224

Manganese/cobalt-catalyzed oxidative C(sp3)–H/C(sp3)–H coupling: a route to α-tertiary β-arylethylamines

M. Tan, K. Li, J. Yin and J. You, Chem. Commun., 2018, 54, 1221 DOI: 10.1039/C7CC08512E

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